Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema
نویسندگان
چکیده
In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.
منابع مشابه
Immune Modulation of B. terrestris Worker (a Type of Bumblebee), Extract on CFA-induced Paw Edema in Rats
To develop a composition for enhancing immunity, based on alcohol extracts of the bumblebee as an active ingredient, bumblebee ethanol extracts were evaluated for their protective effect in chronic models of inflammation, adjuvant induced rat arthritis. B. terrestris worker extract (SDIEX) and, B. hypocrita sapporoensis lava an pupa extract (SPDYBEX), significantly decreased paw edema in arthri...
متن کاملAnti-inflammatory effects of Urtica pilulifera l. seeds extracts in the rat
Urtica pilulifera l. seeds extracts (Decocted and Methanolic extracts) have anti-inflammatory effects. In an experimental-interventional study, Anti-inflammatory effects of Urtica pilulifera l. (UPL), a Traditional Iranian Medicine (TIM) plant, were examined with formalin-induced hind paw edema model in the rat. Sodium salicylate (S.S) injection (300 mg/kg; IP) was used as a positive control gr...
متن کاملAnti-inflammatory effects of Urtica pilulifera l. seeds extracts in the rat
Urtica pilulifera l. seeds extracts (Decocted and Methanolic extracts) have anti-inflammatory effects. In an experimental-interventional study, Anti-inflammatory effects of Urtica pilulifera l. (UPL), a Traditional Iranian Medicine (TIM) plant, were examined with formalin-induced hind paw edema model in the rat. Sodium salicylate (S.S) injection (300 mg/kg; IP) was used as a positive control gr...
متن کاملSynovial fractalkine plays important role in cytokines’ related knee edema variation in rat arthritis model
Introduction: The systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. This study was purposed to verify the roles of synovial TNF-α, IL-6 and fractalkine (Fkn) in edema changes during different stages of Complete Freund’s Adjuvant (CFA)-induced knee arthritis in rats. Methods: 168 male Wistar rats were divided i...
متن کاملThe anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema
Objective(s):Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine a...
متن کامل